IMAGING AND MULTI-OMICS DATASETS CONVERGE TO DEFINE DIFFERENT NEURAL PROGENITOR ORIGINS FOR ATRT-SHH SUBGROUPS

Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups

Abstract Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, Utility suggesting diverse lineages of origin.Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-CreERT2::Smarcb1flox/flox model.This cross-species analysis points to an extra-cerebral

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Ethical challenges of the healthcare transition to adult antiretroviral therapy (ART) clinics for adolescents and young people with HIV in Uganda

Abstract Background Whereas many adolescents and young people with HIV require the transfer of care from paediatric/adolescent clinics to adult ART clinics, this transition is beset with a multitude of factors that have the potential to hinder or facilitate the process, thereby raising ethical Media Stand challenges of the transition process.Decisi

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Clinical and electrodiagnostic findings in a cohort of 61 dogs with peripheral nervous system diseases - a retrospective study

The electrodiagnostic Stickers examination provides the basis for a diagnostic workup in diseases involving nerve roots, peripheral nerves, neuromuscular junctions and muscles in humans and animals.It is a functional test that enables identification, localization and characterization of the disease within the peripheral nervous system.The study was

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Enhancing chemoimmunotherapy for colorectal cancer with paclitaxel and alantolactone via CD44-Targeted nanoparticles: A STAT3 signaling pathway modulation approach

Chemoimmunotherapy has the potential to enhance chemotherapy and modulate the immunosuppressive tumor microenvironment by activating immunogenic cell death (ICD), making it a promising strategy for clinical application.Alantolactone (A) was found to augment the anticancer efficacy of paclitaxel (P) at a molar Stickers ratio of 1:0.5 (P:A) through i

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